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My only hesitation in accepting the hypothesis that obesity is a downstream effect of hypothalamic inflammation lies in the fact that, in metabolically healthy individuals, a normally functioning digestive system, a non-steatotic liver, nutrient-sensitive pancreas and intestine, insulin-sensitive adipose tissue, should mitigate, at least to some extent (though not completely), the negative effects of an unhealthy diet, until their compensatory capacity fails

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1 Introduction 1.1 Physiological actions of GIP Glucose-dependent insulinotropic polypeptide (GIP) is a 42 amino acid-peptide and gut-derived hormone